Fresh analysis indicates that individuals who stop using blockbuster weight-loss injections like Wegovy and Mounjaro may regain lost weight much more quickly than those who end traditional lifestyle plans.
Research printed in a prominent medical journal shows that while obese individuals often shed about a fifth of their total mass while using the jabs, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals buying these medications need to be informed of the danger of quick weight regain when the therapy ends," cautioned researcher Dr. Susan Jebb.
Such speed of regain means a reversion to original weight within about a year and a half.
Weighing Approaches
The study, which examined 37 of trials involving over 9,000 of participants, compared the effects of these new drugs with older methods.
Researchers point out that people who lose weight through dieting generally see a slower creep back—perhaps 0.1 kg a month—once they finish.
Understanding the Fast Regain
Experts suggest the mechanism of the injections is key to understanding the heightened rebound.
The injections imitate a natural hormone called GLP-1, which controls feelings of fullness.
"Sustained high doses of the hormone concentrations far above than the body's typical production might result in the body to generate a reduced amount of its own natural hormone, and could reduce responsiveness to its effects," said Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this medication leads to appetite is unsuppressed, making binge eating a significant risk."
A Chronic Condition?
The NHS suggest the injections for people with weight-linked medical conditions, alongside recommended diet and exercise modifications.
Many experts contend that, considering the likelihood of weight regain, the therapy might need to be long-term.
This perspective is reinforced by drug manufacturers, who note that the results "highlight the chronic nature of excess weight," similar to managing diseases like hypertension.
Patient Accounts
Users who have discontinued the medication explain a sudden return of hunger.
"It was like a switch flipping and you're instantly extremely hungry," described an individual.
The struggle is exacerbated if users have not adopted sustainable dietary or behavioural changes during therapy.
Growing Interest
Survey data suggest that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with interest remaining high.
- Adoption is greater among women compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many access the medications through private healthcare rather than the NHS.
Finally, clinicians stress that while these medications are potent tools for shedding pounds, they are not a permanent solution and long-term success likely depends on integrated behavioural management.
